1933 Editorial

Canynge Hall 1933-1969

ust over thirty-five years ago the newly formed Univer-Department of Preventive Medicine was opened at anynge Hall, a former hotel (Plate V), by the then 'hister of Health, Sir Hilton Young. He described the ?Ccasion as the celebration of a marriage of the City Bristol with the fair nymph of knowledge, and Dr. anley Badock, in proposing the vote of thanks, hoped at it would be a lasting and hap...

Michael Heidelberger, 1933

Dmd053223 1923..1933

Mefenamic acid (MFA), a carboxylic acid–containing nonsteroidal anti-inflammatory drug, is metabolized into the chemically-reactive MFA-1-O-acyl-glucuronide (MFA-1-O-G), MFA-acyl-adenylate (MFAAMP), and the MFA-S-acyl-coenzyme A (MFA-CoA), all of which are electrophilic and capable of acylating nucleophilic sites on biomolecules. In this study, we investigate the nonenzymatic ability of each MF...

Ddh200 1933..1941

Regulation of cystic fibrosis transmembrane conductance regulator (CFTR) mRNA levels is not well understood. Mouse Cftr mRNA shows strain-dependent expression differences that cannot be fully explained by variation at non-Cftr loci. Differences in tracheal and colonic expression appear to be due predominantly to elements linked to Cftr. Fifteen single nucleotide sequence variations were found w...

George Stell (1933-2014).